A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Ertesvåg, Nina Urke Xiao, Julie Zhou, Fan Ljostveit, Sonja Sandnes, Helene Heitmann Lartey, Sarah Sævik, Marianne Hansen, Lena Madsen, Anders Mohn, Kristin Greve-Isdahl Fjelltveit, Elisabeth Berg Olofsson, Jan Stefan Tan, Tiong Kit Rijal, Pramilia Schimanski, Lisa Øyen, Siri Brokstad, Karl Albert Dunachie, Susanna Jämsén, Anni James, William S Harding, Adam C Harvala, Heli Nguyen, Dung Roberts, David Patel, Monika Gopal, Robin Zambon, Maria Wei, Leiyan Gilbert-Jaramillo, Javier Knight, Michael L Vaughan-Jackson, Alun Dupont, Maeva Lamikanra, Abigail A Klennerman, Paul Townsend, Alain Tøndel, Camilla Kuwelker, Kanika Blomberg, Bjørn Bredholt, Geir Onyango, Therese Bredholt Vahokoski, Juha Bansal, Amit Trieu, Mai Chi Amdam, Håkon Akselsen, Per Espen Skorge, Trude Duelien Okkenhaug, Liv Heiberg Linchausen, Dagrun Waag Langeland, Nina Cox Brokstad, Rebecca Jane |
| description | The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination. |
| format | Article |
| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_3059014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_3059014</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_30590143</originalsourceid><addsrcrecordid>eNqNzDEOglAMgGEWB6PeoR6ABFAHR0I0zmJcSX08sBFa0ldMuL2YeACnf_nyL6NXDooD1YBs9JB6guDUeyZu4Ym-x7btRiNGI2EwHwwaURjU1-Tsq6jvRyabwATK_FrGhdzjDN6oND8DSANO2HnldbRosAt-8-sq2p5Pt-ISO6UwvyoWxSpNs0NS7ZLDMUn3u3_MB6OfQIU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern</title><source>NORA - Norwegian Open Research Archives</source><creator>Ertesvåg, Nina Urke ; Xiao, Julie ; Zhou, Fan ; Ljostveit, Sonja ; Sandnes, Helene Heitmann ; Lartey, Sarah ; Sævik, Marianne ; Hansen, Lena ; Madsen, Anders ; Mohn, Kristin Greve-Isdahl ; Fjelltveit, Elisabeth Berg ; Olofsson, Jan Stefan ; Tan, Tiong Kit ; Rijal, Pramilia ; Schimanski, Lisa ; Øyen, Siri ; Brokstad, Karl Albert ; Dunachie, Susanna ; Jämsén, Anni ; James, William S ; Harding, Adam C ; Harvala, Heli ; Nguyen, Dung ; Roberts, David ; Patel, Monika ; Gopal, Robin ; Zambon, Maria ; Wei, Leiyan ; Gilbert-Jaramillo, Javier ; Knight, Michael L ; Vaughan-Jackson, Alun ; Dupont, Maeva ; Lamikanra, Abigail A ; Klennerman, Paul ; Townsend, Alain ; Tøndel, Camilla ; Kuwelker, Kanika ; Blomberg, Bjørn ; Bredholt, Geir ; Onyango, Therese Bredholt ; Vahokoski, Juha ; Bansal, Amit ; Trieu, Mai Chi ; Amdam, Håkon ; Akselsen, Per Espen ; Skorge, Trude Duelien ; Okkenhaug, Liv Heiberg ; Linchausen, Dagrun Waag ; Langeland, Nina ; Cox Brokstad, Rebecca Jane</creator><creatorcontrib>Ertesvåg, Nina Urke ; Xiao, Julie ; Zhou, Fan ; Ljostveit, Sonja ; Sandnes, Helene Heitmann ; Lartey, Sarah ; Sævik, Marianne ; Hansen, Lena ; Madsen, Anders ; Mohn, Kristin Greve-Isdahl ; Fjelltveit, Elisabeth Berg ; Olofsson, Jan Stefan ; Tan, Tiong Kit ; Rijal, Pramilia ; Schimanski, Lisa ; Øyen, Siri ; Brokstad, Karl Albert ; Dunachie, Susanna ; Jämsén, Anni ; James, William S ; Harding, Adam C ; Harvala, Heli ; Nguyen, Dung ; Roberts, David ; Patel, Monika ; Gopal, Robin ; Zambon, Maria ; Wei, Leiyan ; Gilbert-Jaramillo, Javier ; Knight, Michael L ; Vaughan-Jackson, Alun ; Dupont, Maeva ; Lamikanra, Abigail A ; Klennerman, Paul ; Townsend, Alain ; Tøndel, Camilla ; Kuwelker, Kanika ; Blomberg, Bjørn ; Bredholt, Geir ; Onyango, Therese Bredholt ; Vahokoski, Juha ; Bansal, Amit ; Trieu, Mai Chi ; Amdam, Håkon ; Akselsen, Per Espen ; Skorge, Trude Duelien ; Okkenhaug, Liv Heiberg ; Linchausen, Dagrun Waag ; Langeland, Nina ; Cox Brokstad, Rebecca Jane</creatorcontrib><description>The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination.</description><language>eng</language><publisher>Nature Research</publisher><creationdate>2022</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26544</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/3059014$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Ertesvåg, Nina Urke</creatorcontrib><creatorcontrib>Xiao, Julie</creatorcontrib><creatorcontrib>Zhou, Fan</creatorcontrib><creatorcontrib>Ljostveit, Sonja</creatorcontrib><creatorcontrib>Sandnes, Helene Heitmann</creatorcontrib><creatorcontrib>Lartey, Sarah</creatorcontrib><creatorcontrib>Sævik, Marianne</creatorcontrib><creatorcontrib>Hansen, Lena</creatorcontrib><creatorcontrib>Madsen, Anders</creatorcontrib><creatorcontrib>Mohn, Kristin Greve-Isdahl</creatorcontrib><creatorcontrib>Fjelltveit, Elisabeth Berg</creatorcontrib><creatorcontrib>Olofsson, Jan Stefan</creatorcontrib><creatorcontrib>Tan, Tiong Kit</creatorcontrib><creatorcontrib>Rijal, Pramilia</creatorcontrib><creatorcontrib>Schimanski, Lisa</creatorcontrib><creatorcontrib>Øyen, Siri</creatorcontrib><creatorcontrib>Brokstad, Karl Albert</creatorcontrib><creatorcontrib>Dunachie, Susanna</creatorcontrib><creatorcontrib>Jämsén, Anni</creatorcontrib><creatorcontrib>James, William S</creatorcontrib><creatorcontrib>Harding, Adam C</creatorcontrib><creatorcontrib>Harvala, Heli</creatorcontrib><creatorcontrib>Nguyen, Dung</creatorcontrib><creatorcontrib>Roberts, David</creatorcontrib><creatorcontrib>Patel, Monika</creatorcontrib><creatorcontrib>Gopal, Robin</creatorcontrib><creatorcontrib>Zambon, Maria</creatorcontrib><creatorcontrib>Wei, Leiyan</creatorcontrib><creatorcontrib>Gilbert-Jaramillo, Javier</creatorcontrib><creatorcontrib>Knight, Michael L</creatorcontrib><creatorcontrib>Vaughan-Jackson, Alun</creatorcontrib><creatorcontrib>Dupont, Maeva</creatorcontrib><creatorcontrib>Lamikanra, Abigail A</creatorcontrib><creatorcontrib>Klennerman, Paul</creatorcontrib><creatorcontrib>Townsend, Alain</creatorcontrib><creatorcontrib>Tøndel, Camilla</creatorcontrib><creatorcontrib>Kuwelker, Kanika</creatorcontrib><creatorcontrib>Blomberg, Bjørn</creatorcontrib><creatorcontrib>Bredholt, Geir</creatorcontrib><creatorcontrib>Onyango, Therese Bredholt</creatorcontrib><creatorcontrib>Vahokoski, Juha</creatorcontrib><creatorcontrib>Bansal, Amit</creatorcontrib><creatorcontrib>Trieu, Mai Chi</creatorcontrib><creatorcontrib>Amdam, Håkon</creatorcontrib><creatorcontrib>Akselsen, Per Espen</creatorcontrib><creatorcontrib>Skorge, Trude Duelien</creatorcontrib><creatorcontrib>Okkenhaug, Liv Heiberg</creatorcontrib><creatorcontrib>Linchausen, Dagrun Waag</creatorcontrib><creatorcontrib>Langeland, Nina</creatorcontrib><creatorcontrib>Cox Brokstad, Rebecca Jane</creatorcontrib><title>A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern</title><description>The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNzDEOglAMgGEWB6PeoR6ABFAHR0I0zmJcSX08sBFa0ldMuL2YeACnf_nyL6NXDooD1YBs9JB6guDUeyZu4Ym-x7btRiNGI2EwHwwaURjU1-Tsq6jvRyabwATK_FrGhdzjDN6oND8DSANO2HnldbRosAt-8-sq2p5Pt-ISO6UwvyoWxSpNs0NS7ZLDMUn3u3_MB6OfQIU</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Ertesvåg, Nina Urke</creator><creator>Xiao, Julie</creator><creator>Zhou, Fan</creator><creator>Ljostveit, Sonja</creator><creator>Sandnes, Helene Heitmann</creator><creator>Lartey, Sarah</creator><creator>Sævik, Marianne</creator><creator>Hansen, Lena</creator><creator>Madsen, Anders</creator><creator>Mohn, Kristin Greve-Isdahl</creator><creator>Fjelltveit, Elisabeth Berg</creator><creator>Olofsson, Jan Stefan</creator><creator>Tan, Tiong Kit</creator><creator>Rijal, Pramilia</creator><creator>Schimanski, Lisa</creator><creator>Øyen, Siri</creator><creator>Brokstad, Karl Albert</creator><creator>Dunachie, Susanna</creator><creator>Jämsén, Anni</creator><creator>James, William S</creator><creator>Harding, Adam C</creator><creator>Harvala, Heli</creator><creator>Nguyen, Dung</creator><creator>Roberts, David</creator><creator>Patel, Monika</creator><creator>Gopal, Robin</creator><creator>Zambon, Maria</creator><creator>Wei, Leiyan</creator><creator>Gilbert-Jaramillo, Javier</creator><creator>Knight, Michael L</creator><creator>Vaughan-Jackson, Alun</creator><creator>Dupont, Maeva</creator><creator>Lamikanra, Abigail A</creator><creator>Klennerman, Paul</creator><creator>Townsend, Alain</creator><creator>Tøndel, Camilla</creator><creator>Kuwelker, Kanika</creator><creator>Blomberg, Bjørn</creator><creator>Bredholt, Geir</creator><creator>Onyango, Therese Bredholt</creator><creator>Vahokoski, Juha</creator><creator>Bansal, Amit</creator><creator>Trieu, Mai Chi</creator><creator>Amdam, Håkon</creator><creator>Akselsen, Per Espen</creator><creator>Skorge, Trude Duelien</creator><creator>Okkenhaug, Liv Heiberg</creator><creator>Linchausen, Dagrun Waag</creator><creator>Langeland, Nina</creator><creator>Cox Brokstad, Rebecca Jane</creator><general>Nature Research</general><scope>3HK</scope></search><sort><creationdate>2022</creationdate><title>A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern</title><author>Ertesvåg, Nina Urke ; Xiao, Julie ; Zhou, Fan ; Ljostveit, Sonja ; Sandnes, Helene Heitmann ; Lartey, Sarah ; Sævik, Marianne ; Hansen, Lena ; Madsen, Anders ; Mohn, Kristin Greve-Isdahl ; Fjelltveit, Elisabeth Berg ; Olofsson, Jan Stefan ; Tan, Tiong Kit ; Rijal, Pramilia ; Schimanski, Lisa ; Øyen, Siri ; Brokstad, Karl Albert ; Dunachie, Susanna ; Jämsén, Anni ; James, William S ; Harding, Adam C ; Harvala, Heli ; Nguyen, Dung ; Roberts, David ; Patel, Monika ; Gopal, Robin ; Zambon, Maria ; Wei, Leiyan ; Gilbert-Jaramillo, Javier ; Knight, Michael L ; Vaughan-Jackson, Alun ; Dupont, Maeva ; Lamikanra, Abigail A ; Klennerman, Paul ; Townsend, Alain ; Tøndel, Camilla ; Kuwelker, Kanika ; Blomberg, Bjørn ; Bredholt, Geir ; Onyango, Therese Bredholt ; Vahokoski, Juha ; Bansal, Amit ; Trieu, Mai Chi ; Amdam, Håkon ; Akselsen, Per Espen ; Skorge, Trude Duelien ; Okkenhaug, Liv Heiberg ; Linchausen, Dagrun Waag ; Langeland, Nina ; Cox Brokstad, Rebecca Jane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_30590143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Ertesvåg, Nina Urke</creatorcontrib><creatorcontrib>Xiao, Julie</creatorcontrib><creatorcontrib>Zhou, Fan</creatorcontrib><creatorcontrib>Ljostveit, Sonja</creatorcontrib><creatorcontrib>Sandnes, Helene Heitmann</creatorcontrib><creatorcontrib>Lartey, Sarah</creatorcontrib><creatorcontrib>Sævik, Marianne</creatorcontrib><creatorcontrib>Hansen, Lena</creatorcontrib><creatorcontrib>Madsen, Anders</creatorcontrib><creatorcontrib>Mohn, Kristin Greve-Isdahl</creatorcontrib><creatorcontrib>Fjelltveit, Elisabeth Berg</creatorcontrib><creatorcontrib>Olofsson, Jan Stefan</creatorcontrib><creatorcontrib>Tan, Tiong Kit</creatorcontrib><creatorcontrib>Rijal, Pramilia</creatorcontrib><creatorcontrib>Schimanski, Lisa</creatorcontrib><creatorcontrib>Øyen, Siri</creatorcontrib><creatorcontrib>Brokstad, Karl Albert</creatorcontrib><creatorcontrib>Dunachie, Susanna</creatorcontrib><creatorcontrib>Jämsén, Anni</creatorcontrib><creatorcontrib>James, William S</creatorcontrib><creatorcontrib>Harding, Adam C</creatorcontrib><creatorcontrib>Harvala, Heli</creatorcontrib><creatorcontrib>Nguyen, Dung</creatorcontrib><creatorcontrib>Roberts, David</creatorcontrib><creatorcontrib>Patel, Monika</creatorcontrib><creatorcontrib>Gopal, Robin</creatorcontrib><creatorcontrib>Zambon, Maria</creatorcontrib><creatorcontrib>Wei, Leiyan</creatorcontrib><creatorcontrib>Gilbert-Jaramillo, Javier</creatorcontrib><creatorcontrib>Knight, Michael L</creatorcontrib><creatorcontrib>Vaughan-Jackson, Alun</creatorcontrib><creatorcontrib>Dupont, Maeva</creatorcontrib><creatorcontrib>Lamikanra, Abigail A</creatorcontrib><creatorcontrib>Klennerman, Paul</creatorcontrib><creatorcontrib>Townsend, Alain</creatorcontrib><creatorcontrib>Tøndel, Camilla</creatorcontrib><creatorcontrib>Kuwelker, Kanika</creatorcontrib><creatorcontrib>Blomberg, Bjørn</creatorcontrib><creatorcontrib>Bredholt, Geir</creatorcontrib><creatorcontrib>Onyango, Therese Bredholt</creatorcontrib><creatorcontrib>Vahokoski, Juha</creatorcontrib><creatorcontrib>Bansal, Amit</creatorcontrib><creatorcontrib>Trieu, Mai Chi</creatorcontrib><creatorcontrib>Amdam, Håkon</creatorcontrib><creatorcontrib>Akselsen, Per Espen</creatorcontrib><creatorcontrib>Skorge, Trude Duelien</creatorcontrib><creatorcontrib>Okkenhaug, Liv Heiberg</creatorcontrib><creatorcontrib>Linchausen, Dagrun Waag</creatorcontrib><creatorcontrib>Langeland, Nina</creatorcontrib><creatorcontrib>Cox Brokstad, Rebecca Jane</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ertesvåg, Nina Urke</au><au>Xiao, Julie</au><au>Zhou, Fan</au><au>Ljostveit, Sonja</au><au>Sandnes, Helene Heitmann</au><au>Lartey, Sarah</au><au>Sævik, Marianne</au><au>Hansen, Lena</au><au>Madsen, Anders</au><au>Mohn, Kristin Greve-Isdahl</au><au>Fjelltveit, Elisabeth Berg</au><au>Olofsson, Jan Stefan</au><au>Tan, Tiong Kit</au><au>Rijal, Pramilia</au><au>Schimanski, Lisa</au><au>Øyen, Siri</au><au>Brokstad, Karl Albert</au><au>Dunachie, Susanna</au><au>Jämsén, Anni</au><au>James, William S</au><au>Harding, Adam C</au><au>Harvala, Heli</au><au>Nguyen, Dung</au><au>Roberts, David</au><au>Patel, Monika</au><au>Gopal, Robin</au><au>Zambon, Maria</au><au>Wei, Leiyan</au><au>Gilbert-Jaramillo, Javier</au><au>Knight, Michael L</au><au>Vaughan-Jackson, Alun</au><au>Dupont, Maeva</au><au>Lamikanra, Abigail A</au><au>Klennerman, Paul</au><au>Townsend, Alain</au><au>Tøndel, Camilla</au><au>Kuwelker, Kanika</au><au>Blomberg, Bjørn</au><au>Bredholt, Geir</au><au>Onyango, Therese Bredholt</au><au>Vahokoski, Juha</au><au>Bansal, Amit</au><au>Trieu, Mai Chi</au><au>Amdam, Håkon</au><au>Akselsen, Per Espen</au><au>Skorge, Trude Duelien</au><au>Okkenhaug, Liv Heiberg</au><au>Linchausen, Dagrun Waag</au><au>Langeland, Nina</au><au>Cox Brokstad, Rebecca Jane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern</atitle><date>2022</date><risdate>2022</risdate><abstract>The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination.</abstract><pub>Nature Research</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_cristin_nora_11250_3059014 |
| source | NORA - Norwegian Open Research Archives |
| title | A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T20%3A19%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-cristin_3HK&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20rapid%20antibody%20screening%20haemagglutination%20test%20for%20predicting%20immunity%20to%20SARS-CoV-2%20variants%20of%20concern&rft.au=Ertesv%C3%A5g,%20Nina%20Urke&rft.date=2022&rft_id=info:doi/&rft_dat=%3Ccristin_3HK%3E11250_3059014%3C/cristin_3HK%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |