A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern

The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood...

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Hauptverfasser:	Ertesvåg, Nina Urke, Xiao, Julie, Zhou, Fan, Ljostveit, Sonja, Sandnes, Helene Heitmann, Lartey, Sarah, Sævik, Marianne, Hansen, Lena, Madsen, Anders, Mohn, Kristin Greve-Isdahl, Fjelltveit, Elisabeth Berg, Olofsson, Jan Stefan, Tan, Tiong Kit, Rijal, Pramilia, Schimanski, Lisa, Øyen, Siri, Brokstad, Karl Albert, Dunachie, Susanna, Jämsén, Anni, James, William S, Harding, Adam C, Harvala, Heli, Nguyen, Dung, Roberts, David, Patel, Monika, Gopal, Robin, Zambon, Maria, Wei, Leiyan, Gilbert-Jaramillo, Javier, Knight, Michael L, Vaughan-Jackson, Alun, Dupont, Maeva, Lamikanra, Abigail A, Klennerman, Paul, Townsend, Alain, Tøndel, Camilla, Kuwelker, Kanika, Blomberg, Bjørn, Bredholt, Geir, Onyango, Therese Bredholt, Vahokoski, Juha, Bansal, Amit, Trieu, Mai Chi, Amdam, Håkon, Akselsen, Per Espen, Skorge, Trude Duelien, Okkenhaug, Liv Heiberg, Linchausen, Dagrun Waag, Langeland, Nina, Cox Brokstad, Rebecca Jane
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Sprache:	eng
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Zusammenfassung:	The aim of this study was to rapidly investigate the immune responses after SARS-CoV-2 infection and vaccination of younger adults and the elderly. Antibodies are proteins produced by the immune system that are released into the bloodstream and help fight infections. A simple method using red blood cells obtained from blood was developed and used to detect antibodies to SARS-CoV-2. This test was able to measure protective antibodies to several variants of concern. The elderly had lower antibody responses after vaccination. Two vaccinations induced a broader antibody response to viral variants, similar to the response induced following Covid-19. This antibody detection method could be used as a finger prick test to rapidly detect specific antibodies to emerging variants and enable quick identification of individuals who might benefit from a booster vaccination.