Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 si...

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Hauptverfasser:	Tang, Clara S, Zhang, He, Cheung, Chloe Y.Y, Xu, Ming, Ho, Jenny C.Y, Zhou, Wei, Cherny, Stacey S, Zhang, Yan, Holmen, Oddgeir, Au, Ka-Wing, Yu, Haiyi, Xu, Lin, Jia, Jia, Porsch, Robert M, Sun, Lijie, Xu, Weixian, Zheng, Huiping, Wong, Lai-Yung, Mu, Yiming, Dou, Jingtao, Fong, Carol H.Y, Wang, Shuyu, Hong, Xueyu, Dong, Liguang, Liao, Yanhua, Wang, Jiansong, Lam, Levina S.M, Su, Xi, Yan, Hua, Yang, Min-Lee, Chen, Jin, Siu, Chung-Wah, Xie, Gaoqiang, Woo, Yu-Cho, Wu, Yangfeng, Tan, Kathryn C.B, Hveem, Kristian, Cheung, Bernard M.Y, Zöllner, Sebastian, Xu, Aimin, Chen, Y. Eugene, Jiang, Chao Qiang, Zhang, Youyi, Lam, Tai-Hing, Ganesh, Santhi K, Huo, Yong, Sham, Pak C, Lam, Karen S.L, Willer, Cristen J, Tse, Hung-Fat, Gao, Wei
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P