Molecular pathological insights reveal a high number of unfavorable risk patients among children treated for medulloblastoma and CNS‐PNET in Oslo 2005–2017

Background An unexplained regional difference in survival was observed in previous publications on outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS‐PNET) in Norway. We aimed now to reevaluate and perform a retrospective molecular‐based risk str...

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Veröffentlicht in:	Pediatric blood & cancer 2022-09, Vol.69 (9), p.e29736-n/a
Hauptverfasser:	Niehusmann, Pitt, Stensvold, Einar, Leske, Henning, Pietsch, Torsten, Goschzik, Tobias, Gielen, Gerrit H., Due‐Tønnessen, Bernt, Frič, Radek, Nilssen, Yngvar, Brandal, Petter
Format:	Artikel
Sprache:	eng
Schlagworte:	BCOR Brain cancer Brain tumors Central nervous system Chromosome aberrations Classification CNS neuroblastoma DNA methylation Gene expression Hematology Medical prognosis Medulloblastoma molecular pathology Nervous system diseases Neuroblastoma Norway Oncology Patients PATZ1 Pediatrics risk stratification Survival Tumors Wnt protein
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Zusammenfassung:	Background An unexplained regional difference in survival was observed in previous publications on outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS‐PNET) in Norway. We aimed now to reevaluate and perform a retrospective molecular‐based risk stratification of all embryonal brain tumors (excluding atypical teratoid rhabdoid tumors [ATRT]) in pediatric patients, who underwent surgery and treatment at Oslo University Hospital between 2005 and 2017. Procedure Specimens from all patients
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.29736