Solitary fibrous tumour. The role of clinical, histopathological and molecular factors in risk stratification and prognosis

Solitary fibrous tumour (SFT) is a very rare fibroblastic soft tissue tumour which is characterized by a pathognomonic NAB2-STAT6 gene fusion. Up to 30% of the tumours will recur including both local recurrence and metastasis. It is difficult to predict how every single SFT will behave after the initial curatively intended surgery, particularly in a longer term. The patients are still at risk of recurrence even after 10 years, and historically used signs of malignancy don´t seem to correlate with prognosis. In the present thesis «Solitary fibrous tumour. The role of clinical, histopathological and molecular factors in risk stratification and prognosis» Tatiana Georgiesh and co-authors have studied different prognostic factors in a patient cohort with long-term follow-up. The findings comprised a fundamental for a novel risk score which has been successfully validated in an external international cohort and could accurately risk stratify patients including prediction of late recurrences. The results of the included studies might potentially improve the prognostic possibilities for SFT patients for better follow-up and treatment considerations.