STUDIES ON SOME BIOACTIVE N-p-METHACRYLAMIDOBENZOIC ESTERS

<正> In a previous article, we reported tho syntheses of some bioactive polyacryloc esters and the coupling of trypsin or serum protein onto polyaerylie esters by the active ester method of N-hydroxy compounds. We have observed that a hydrophobic and rigid benzene ring as a spacing group between the main chain and the protein seems to be a dominant factor for the high biologieal activity of the immobilized enzyme. Poly (N-p-methaeryloxybenzoloxy-5-norbornene-2, 3-diearboxhnide)-trypsin [P (MBONB)-try-psin] matrix exhibited a bioactivity around three times that of the poly (N-metha-