Effect of erythroid enhancer on P globin gene expression

Effect of erythroid enhancer on P globin gene expression

<正> β-Thalassamia, one of the severe genetic diseases, is now being treated with genetherapy by transferring the normal human β globin gene into the patient’s stem cells andmaking it stably and adequately express a long time, in recent years. Our previous workverified that a 36bp fragm...

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Veröffentlicht in:自然科学进展：英文版 1996 (4), p.120-124
Hauptverfasser: 韦启泽, 刘德培, 陶吉中, 刘庆辉, 贾佩臣, 雷学锋, 陈松森, 梁植权
Format: Artikel
Sprache:eng
Schlagworte:
enhancer
β
erythroid
gene
retrovirus
globin
vector
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Zusammenfassung:<正> β-Thalassamia, one of the severe genetic diseases, is now being treated with genetherapy by transferring the normal human β globin gene into the patient’s stem cells andmaking it stably and adequately express a long time, in recent years. Our previous workverified that a 36bp fragment containing the NFE-2/AP-1 protein binding site in 5’hypersensitive site 2 (5’ HS2) raised the expression level of β globin gene in MEI cells by 2-
ISSN:1002-0071