Lingual flange protrusion： diagnostic marker for metastatic liver cancer

OBJECTIVE： To investigate the diagnostic signifi-cance of lingual flange protrusion for liver metasta-sis of patients with malignant neoplasia.METHODS： The data of 191 patients with malig-nant neoplasia were analyzed. All photos of pa-tients＇ tongue image were recorded and lingualflange protrusion was the positive standard. X2 testfor paired data and Kappa test were used to deter-mine the diagnostic value of lingual flange protru-sion for metastatic liver cancer. Mann-Whitney Utest was used to compare the levels of liver serolog-ical markers. The area under receiver operatingcharacteristic curve （ROC） and logistic regressionmodel were used to analyze the predictive valuesof lingual flange protrusion, alkaline phosphatase（ALP）, and lactate dehydrogenase （LDH） levels.