Mathematical modeling for of arctigenin from acidultrasonic-assisted extractionhydrolyzed FructusArctii

A mathematical model based on Fick＇ s first law wasestablished to describe the process of ultrasonic-assistedextraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid promotes theconversion of arctiin to arctigenin in the arctiin-rich activepharmaceutical ingredient, and the hydrolyzed products werefurther examined to investigate the process setup. Byconsidering the mechanism of the extraction process andexperimental data, the effects of parameters including solventto solid ratio, particle size of hydrolyzed samples, ethanolvolume fraction, ultrasound power, extraction temperature andextraction time on concentration of arctigenin were analyzed indetail. The model was suitable for simulating the process ofultrasonic-assisted extraction of arctigenin. The simulationresults of the model agree well with experimental data with thedeviation below 13%, indicating that the mathematical modelcan provide valuable guidance for the extraction of arctigeninfrom acid hydrolyzed FructusArctii.