The correlation between the level of Lp-PLA2 and coronary instent restenosis after PCI

Background Coronary in-stent restenosis （ISR） is an important complication of percutaneous coronary intervention （PCI）. However, the relationship between lipoprotein associated phospholipase A2 （Lp- PLA2） level and coronary ISR after PCI is rarely reported. Methods 30 patients with coronary ISR after PCI were recruited as the experimental group, 63 patients without coronary ISR after PCI were served as the control group. Lp-PLA2, hypersensitive C-reactive protein （Hs-CRP） and Low density lipoprotein cholesterol （LDL-C） were mea- sured respectively. Smoking, hypertension, diabetes mellitus and other related factors were recorded. The relation-ships between these factors and restenosis of coronary stent after PCI were analyzed. Results The correlation analysis showed statistically significant （P〈0.05） between the level of Lp-PLA2, Hs-CRP and the restenosis of coronary stent after PCI, and that Lp-PLA2 level was an independent risk factor for coronary ISR after PCI. The correlation of Lp-PLA2 to ISR was superior to that of Hs-CRP to ISR. Conclusion The increased level of Lp- PLA2 is correlated to coronary ISR after PCI. Therefore, plasma level of Lp-PLA2 may be used as a clinically useful marker for coronary ISR prediction in patients undergoing PCI.