Highly Efficient Synthesis of a-Halomethylketones via Ce（SO4）2/Acid Co-Catalyzed Hydration of Alkynes

Highly Efficient Synthesis of a-Halomethylketones via Ce（SO4）2/Acid Co-Catalyzed Hydration of Alkynes

A general atom-economical approach for the synthesis of a-halomethyl ketones is demonstrated through Ce（SO4）z/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent...

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Veröffentlicht in:中国化学：英文版 2016, Vol.34 (12), p.1251-1254
1. Verfasser: Huaxu Zou Jun Jiang Niannian Yi Wenqiang Fu Wei Deng Jiannan Xiang
Format: Artikel
Sprache:eng
Schlagworte:
催化水合
原子经济性
水化
炔烃
酮类化合物
钴
高效合成
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Zusammenfassung:A general atom-economical approach for the synthesis of a-halomethyl ketones is demonstrated through Ce（SO4）z/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional a-halogenation of ketones.
ISSN:1001-604X
1614-7065