Activity of tamarindus indica pulp water extract in high carbohydrate dietrats as a treatment for obesity and insulin resistance

Obesity is often identified as a nutritional disorder, and this condition continues to be one of the most important yetpreventable health hazards. It may be a complex group of diseases and should be characterized as a syndrome that results from animbalance between energy intake and expenditure. Furthermore, obesity is associated with several diseases such as diabetesmellitus, atherosclerosis, cardiovascular diseases, osteoarthritis, and hypertension. In previous studies, we found that in Asia,especially in the Asean region, carbohydrates are heavily represented in the diet. Therefore, we used a high carbohydrate diet toinduce obesity in rats. The aim of this study was to evaluate the potency of Tamarindus indica pulp as an anti-obesity agent ina high carbohydrate diet animal model. The antiobesity effect was evaluated in this in vivo model at doses of 75 mg/kg.bw and225 mg/kg.bw. Treatment was started in week 3 and week 9, and biochemical characteristics were measured every 3 weeks.In the end of the study period, insulin resistance and adiponectin levels were measured. TIWE （Tamarindus indica water extract）at a dose of 75 mg/kg.bw showed better efficacy than at a dose of 225 mg/kg-bw, and treatment started on week 3 was better thantreatment started on week 9. TIWE has an anti-obesity effect associated insulin resistance by increasing adiponectin levels andinsulin sensitivity, which can impact body weight, trielyceride levels, blood glucose levels, and body fat.