Ins（1,4,5）P3 Suppresses Protein Degradation in Plant Vacuoles by Regulating SNX-Mediated Protein Sorting

Dear Editor, Protein degradation is an essential process for protein dynamics and the development of living organisms, and defective protein degradation can lead to abnormalities in protein accumulation and cell functions. In addition to the conserved proteasome- dependent pathway in both mammals and plants, the lytic vacuole-dependent pathway is crucial for protein degradation in plants （Cai et al., 2014）.