Interaction of 1,2-Diaminoimidazoles with Ethoxymythelene-Containing Compounds

Interaction of 1, 2-diaminoimidazole with ethoxymethylene-containing derivatives has been studied. It is determined that the interaction malondinitrile, cyanoacetic ester, acetylacetone leads to linearly linked products： 2-[[（2-amino-4-phenyl- 1H-imidazole-l-yl）amino] methylene1 propanedinitrile, ethyl ester 2-[（2-emino-4-phenyl-lH-imidazole-l-yl）amino]-2-cyano-2-propanoic acid and 2-[[（2-amino-4-phenyl-lH-imodazole-l-yl）amino] methylene]-2,4-pentanedoine. An exception is the reaction of ethoxymethylene ester, in the result of which 7-arnino-2-methyl-5-phenyl-imidazol [1, 5-b] pyridine-3-carboxylic acid ethyl ester is regioselectively formed. The products are obtained regardless of reaction condition. The structures of resulting compound are confirmed by NMR ^1H and mass spectroscopy. Further cyclization of linear intermediates with acetic acid, triethylamine, dimethylformamide and dioxane has led to asphaltization that implies difficulties of further individualize derived substances.