Theoretical studies on s RNA-mediated regulation in bacteria

Small RNA（sRNA）-mediated post-transcriptional regulation differs from protein-mediated regulation. Through basepairing, sRNA can regulate the target m RNA in a catalytic or stoichiometric manner. Some theoretical models were built for comparison of the protein-mediated and sRNA-mediated modes in the steady-state behaviors and noise properties. Many experiments demonstrated that a single sRNA can regulate several m RNAs, which causes crosstalk between the targets.Here, we focus on some models in which two target mRNAs are silenced by the same sRNA to discuss their crosstalk features. Additionally, the sequence-function relationship of sRNA and its role in the kinetic process of base-pairing have been highlighted in model building.