Genetic Effects on Sensorineural Hearing Loss andEvidence-based Treatment for SensorineuralHearing Loss

In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss（SNHL）, i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations.For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especiallywhen the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize themost recent evidence-based treatment in this field, which includes gene therapy and allotransplantationof stem cells. Their promising results have shown that they might be options of treatment for profoundSNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpfulto be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.