Convenient synthesis of bis(indolyl)alkanes by dithiocarbohydrazone Schiff basefZn(ClO4)2.6H20 catalyzed Friedel-Crafts reaction of indoles with imines

A new, convenient and excellent yield procedure for the preparation of bis(indolyl)methanes (BIMs) by Friedel-Crafts reaction of indoles with imines in the presence of dithiocarbohydrazone Schiff base/ Zn(CIO4)2.6H2O as a highly stable, effective and readily available catalyst is described. Moderate...

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Veröffentlicht in:中国化学快报:英文版 2014 (1), p.163-165
1. Verfasser: Yong-Hai Hui Yong-Cheng Chen Hai-Wei Gong Zheng-Feng Xie
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Sprache:eng
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Zusammenfassung:A new, convenient and excellent yield procedure for the preparation of bis(indolyl)methanes (BIMs) by Friedel-Crafts reaction of indoles with imines in the presence of dithiocarbohydrazone Schiff base/ Zn(CIO4)2.6H2O as a highly stable, effective and readily available catalyst is described. Moderate to good yields (up to 99% yield) were obtained with both substrates for imine derivatives. This procedure is simple, practical and economic.
ISSN:1001-8417
1878-5964