Pretreatment with Jieduxiezhuo decoction impedes elevations in se- rum uric acid levels in mice

OBJECTIVE： To investigate whether Jieduxiezhuo decoction （JDXZD） can prevent serum uric acid ele- vations in mice. METHODS： Hyperuricemia in mice was induced by intraperitoneally administering uric acid （250 mg/ kg）. Concentrations of uric acid in serum were de- termined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. RESULTS： After intraperitoneal injection of uric ac- id, serum uric acid concentrations in mice signifi- cantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. CONCLUSION： Pretreatment with JDXZD slowed in- creases in serum uric acid levels in mice intraperito-neally administered uric acid.