Comparative Assessment of the Upstream and Downstream Water Qualities of River Tano in Ghana

River Tano, located in the Brong Ahafo region of Ghana, has a number of socio-ecological functions. Anthropogenic activities such as farming, washing, and discharge of industrial effluents into the river pose serious threat to human health. In view of this, water quality campaign was carried out for a period of 12 months by taking samples from the source and the downstream end of the river and analysing for some physico-chemical parameters. The results showed that most of the physico-chemical parameters such as pH, fluoride, nitrite, manganese and temperature were not within the regulatory safe limit. Although the levels of total alkalinity, total iron, ammonia and phosphate kept fluctuating along the course of the river, the difference were not statistically significant apart from fluoride and phosphate which showed significant difference between the upstream and downstream levels. This may be attributed to anthropogenic activities such as farming and washing in the river which implies that human activities