Effect of Liandouqingmai Recipe on life quality and vascular endo- thelial injury in patients with coronary heart disease

OBJECTIVE： To observe the effects of Liandouqing- mai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease. METHODS： Capitalized 101 patients with coronary heart disease were randomly divided into a treat- ment group （n=45） treated with Liandouqingmai Recipe and a standard treatment group （control group, n=56）. A normal group of 16 healthy per- sons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Ques- tionnaire （SAQ） was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software. RESULTS： The average level of ET-1 in the normal group was lower and NO higher than that of pa- tients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limita- tion （PL）, pngina stability （AS）, apngina frequency （AF）, treatment satisfaction （TS） and disease percep- tion （DP）] between the two groups before treat- ment （P〉0.05）. But after treatment, the scores of SAQ （PL, AS, AF, TS, DP） and NO level were higher than those in the control group, and ET-1 average level in the treatment group was lower than that in the control group. The negative relations between PL and ET-1 and between AF and ET-1 were found in this study. CONCLUSION： Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment, thus improving vascular endothelial function and life quality. Life quality is related to vascular endothelial function.