Structural insights into DndE from Escherichia coil B7A involved in DNA phosphorothioation modification

Dear Editor, DNA phosphorothioate （PT） modification, originally developed as an artificial tool to stabilize oligodeoxynucleotides against nuclease degradation , was recently found to be incorporated with sulfur into DNA backbone as a novel physiological variation by the five-gene dnd cluster （dndA-dndE） products in a sequence- and stereo-specific manner .