Glycyrrhizin attenuates HMGBl-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway

Glycyrrhizin attenuates HMGBl-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway

AIM： To examine how High-mobility group box I （HMGB1） regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin （GL）, a known HMGB1 inhibitor, prevents HMGBl-induced hepatocyte apoptosis.

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Bibliographische Detailangaben
Veröffentlicht in:世界胃肠病学杂志：英文版 2012, Vol.18 (7), p.679-684
1. Verfasser: Geum-Youn Gwak Tae Gun Moon Dong Ho LeeI Byung Chul Yoo
Format: Artikel
Sprache:eng
Schlagworte:
HMGB1
P38
甘草甜素
线粒体
细胞凋亡
肝
诱导
高机动性
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Zusammenfassung:AIM： To examine how High-mobility group box I （HMGB1） regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin （GL）, a known HMGB1 inhibitor, prevents HMGBl-induced hepatocyte apoptosis.
ISSN:1007-9327
2219-2840