Model for toxicity of substituted aromatic compounds to aquatic organisms

Quantitative structure-activity relationship(QSAR)models have been widely used topredict the bioactivity of organic compounds,some of them are representative methods,such as the octanol/water partition coefficients,the linear solvation energy relationshipmethod and the molecular connectivity index method.Though used successfully to predictthe toxicity of organic compounds to aquatic organisms,they do not reflect the toxicity