HBsAg携带母亲所生婴幼儿HBV标志物动态变化分析

Objective To investigate the dynamic changes in hepatitis B virus serologic markers（HBVM） in infants born by HBsAg-carrying mothers,who were immunized with high-titer immunoglobulin（HTIG） and hepatitis B vaccine,and evaluate the clinical and epidemiological significance thereof.Methods Two hundred and nine HBsAg-carrying pregnant women and their 213 newborns（4 twins） were consecutively involved from Dec.2002 to Oct.2004,and followed up when infants were at 1,7,12,24 and 36 months of age.HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc in neonatal sera were detected by ELISA.Results One hundred and eighty-two infants（85.45%） born of HBsAg-positive mothers were followed up.Of them 13 were HBsAg positive at birth.At the end of follow-up,all of them changed negative except two cases who were persistently positive for HBsAg.No one in 169 infants who were HBsAg-negative at birth changed to HBsAg-positive.About 57.69%（30/52） neonates born by both HBsAg and HBeAg positive mothers showed detectable levels of HBeAg.Similar t