Observations on the Therapeutic Effects of Anisodamine on Respiratory Distress Syndrome

The animal model of dogs was used to study the pathological evolution ofrespiratory distress syndrome （RDS） and the therapeutic effects of anisodaine on the disease.Atotal of 54 dogs were employed and they were divided into control and experimental groups.RDS was inflicted to the dogs by oleic acid injection.Then the clinical manifestations,theblood gas parameters,the pulmonary arterial pressure,the pulmonary wedge pressure,T3 andTL,blood cell counts,neutrophil aggregation rate,platelet maximum aggregation rate,TXB2,6-keto-PGF1a and hemocoagulagrams were obsenved.On the basis of our observations,it is concluded that the complement activities andneutrophil aggregation induced by TXA2 are likely the initiative factor of RDS,the pathologicalprocess in the lungs is complicated with disseminated intravascular coagulation,and anisodamineexerts certain therapeutic effects on RDS through preventing the cellular membranes andlysosomes from being injured.