THE VARIANCE OF ESTERASE D IN RETINOBLASTOMA

THE VARIANCE OF ESTERASE D IN RETINOBLASTOMA

Esterase D (EsD) was evaluated in 20 patients with retinoblastoma (RB). The EsD activity of the hemolysates of three unilateral cases was normal and the EsD phenotypes of their tumor cells were zero. In another three cases, including one patient with bilateral RB, the EsD was heterozygous, but the t...

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Veröffentlicht in:中国癌症研究：英文版 1989 (1), p.69-72
1. Verfasser: 王和 丘建春 李世绩 周宏远 高秀坤 方谦逊 罗成仁 李安仁
Format: Artikel
Sprache:eng
Schlagworte:
alleles
bilateral
deletion
explained
hemoglobin
phenotype
retinoblastoma
sporadic
tumorigenesis
unilateral
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Zusammenfassung:Esterase D (EsD) was evaluated in 20 patients with retinoblastoma (RB). The EsD activity of the hemolysates of three unilateral cases was normal and the EsD phenotypes of their tumor cells were zero. In another three cases, including one patient with bilateral RB, the EsD was heterozygous, but the tumor cells expressed enzyme from only one of the two EsD alleles. These results provided fresh evidence for Comings’ theory of tumorigenesis in which the production of sporadic nonhereditary RB has been explained.
ISSN:1000-9604
1993-0631