PHOTODYNAMIC AND PHOTOBIOLOGICAL ACTION OF SULFONATED PHTHALOCYANINES

Zinc sulfonated phthalocyanlne (ZnSPc) 10 - 20 mg/ kg plus light showed strong inhibition on mouse S-180 and RA795 lung carcinoma, Inhibition rate was 44.8% and 57. 4% respectively. Aluminum sulfonated phthalocyanlne (AlSPc) 20 mg/kg plus copper vapor laser or red light, tumor Inhibition rate of S- 180 was 62. 7% and 66. 8% respectively, AISPc 1.25 μg/ml caused severe photohe-molyses of red cells. At the dose of 10 μg/ml plus light, lipld peroxidation of red cell membrane was greatly enhanced. Acetylchollnesterase (AchEs) of red cell membrane inactivated, liver mitochondrial ATPase and microsontal G-6-Pase Inhibited. ZnSPc at the dose of 1. 25 μg/ml caused obvious photodamage on DNA of hepatoma cells.