γANDδCHAIN GENE REARRANGEMENT OF T CELL RECEPTOR IN ACUTE LYMPHOBLASTIC LEUKEMIA
The immunophenotype, rearrangements of T cell receptor(TCR) γ andδchain genes as well as the immunoglobulinheavy chain (IgH)gene were studied in 37 cases ofmorphologically defined acute lymphoblastic leukemia (ALL).According to the expression of differentiation antigens, 8 caseswere classified as T-...
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Veröffentlicht in: | 中华医学杂志:英文版 1994 (1), p.13-19 |
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Sprache: | eng |
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Zusammenfassung: | The immunophenotype, rearrangements of T cell receptor(TCR) γ andδchain genes as well as the immunoglobulinheavy chain (IgH)gene were studied in 37 cases ofmorphologically defined acute lymphoblastic leukemia (ALL).According to the expression of differentiation antigens, 8 caseswere classified as T-ALL, 26 B lineage ALL, 2 acute un-differentiated leukemia (AUL) and myeloid phenotype. An or-der of TCR gene rearrangements was observed in T-ALL,with the rearrangement of δgene preceding that of γgene.Both genes were also found frequently rearranged and / or de-leted in high proportions of the ALL of B cell lineage. Howev-er, the patterns of gene rearrangements were somewhat differ-ent between the T and B lineage ALLs. In contrast, the lgHgene rearrangements were observed only in the B lineage ALL.The immunogenotype analysis of ALL proved to be a usefulmarker of the clonality and provided us with important informa-tion on early human lymphoid differentiation. We concludethat the determination of T |
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ISSN: | 0366-6999 2542-5641 |