Temporal changes in circulating P-selectin, plasminogen activator inhibitor-l, magnesium, and creatine kinase after percutaneous coronary intervention

Objective： This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention （PCI）. Methods： The present study examined serial changes （5 min, 30 min, 2 h, 6 h, and 24 h after PCI） in circulating P-selectin, plasminogen activator inhibitor-1 （PAl-l）, magnesium （Mg）, and creatine kinase-myocardial band fraction （CK-MB） levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up. Results： PCI induced an early elevation of P-selectin, which cor- related positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-I. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respec- tively. Conclusions： Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI.