Left ventricular remodeling in patients with stress hyperglycemia after acute myocardial infarction

Background To investigate the association between left ventricular remodeling and stress hyperglycemia （SH） inpatients with acute anterior wall myocardial Infarction. Methods Patients with acute anterior myocardial infarction and a successful primary percutaneous coronary intervention （PCI） were enrolled and divided into two groups according to the presence or absence of SH. Patients with diabetes mellitus were excluded. Echocardiographic studies were performed on discharge and at 6 month follow-up. Left ventricular （LV） ejection fractions （EF）, LV end-diastolic volume （EDV） and LV end-systolic volume （ESV） were obtained at baseline and at 6 month. Differences between changes of ESV （ΔESV） and changes of EDV （ΔEDV） in the two groups as well as EF improvement rate （ΔEF %） over six month were obtained. Correlation between SH and LV remodeling was investigated. Results （1） At baseline, the level of hemoglobin A1c was significantly higher in SH group （6.9±1.4 vs 6.2±0.8 P=0.04）. Other baseline characteristics, including peak serum creatine kinase MB and LV function, were similar between two groups; （2） EF increased significantly over 6 months in both group with SH（（41.1±7.2）% vs （52.7±8.4）%, P=0.02） and group without SH. （（43.6±8.7）% vs （54.5±9.3）%, P=0.03） （3） Only in SH group, EDV increased significantly at 6 month （139.6±26.7 vs 126.1±26.7 P=0.04）; （4） There was a weak correlation between ΔEDV and the level of fasting plasma glucose on admission.（Pearson’s r=0.35, P0.01）. Conclusions （1） Previous glucose metabolism disorder is at least partially responsible for hyperglycemia on admission; （2） Given successful primary PCI within recommended time interval, left ventricular function improved regardless of whether SH is present or not; （3） The degree of glucose metabolic dysfunction on admission is weakly associated with the remodeling process in 6 months