Gastric ghrelin in relation to gender, stomach topography and Helicobacterpylori in dyspeptic patients
AIM: To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylor/(H pylori) infection, bacterial cytotoxicity, topography and gender.METHODS: The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive)...
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Veröffentlicht in: | World journal of gastroenterology : WJG 2009 (43), p.5409-5417 |
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Sprache: | eng |
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Zusammenfassung: | AIM: To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylor/(H pylori) infection, bacterial cytotoxicity, topography and gender.METHODS: The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dyspepsia. All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis. Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay. The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction.RESULTS: In general, infection with H pylori caused an increase in gastric ghrelin level regardless of gender and stomach topography. Significantly more hormone was present in both, non-infected and H pylori positive female samples, as compared to males. The distribution of bacterial strains showed cagA(+) vacA slml and cagA(-) vacA s2m2 genotypes as the most common infections in the studied population. A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative) strain-containing specimens from the antrum and corpus of both gender groups (without statistical significance). CONCLUSION: An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA(-) strains, can exert a gastroprotective effect. |
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ISSN: | 1007-9327 2219-2840 |