Clinicopathological Features of Endometrial Carcinoma Associated with Lynch Syndrome in China

Background and objective To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China. Methods Twenty-seven patients who fulfilled the Amsterdam Criteria II were classified as having Lynch syndrome-associated endometrial carcinoma （Group A）, and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma （Group B）. Results There were 81 malignancies in 27 Lynch syndrome-associated endometrial carcinoma families, including colorectal cancer （CRC, 24.7%）, endometrial carcinoma （21.0%）, liver （12.3%）, stomach （9.9%）, lung （6.2%）, and breast （6.2%） cancers. Mean age at time of diagnosis was 49.7 years in Group A and 56.3 years in Group B （P=0.004）. Second primary cancers occurred in 33.3% of patients in Group A and 5.1% in Group B （P〈0.0001）. The most common second primary cancers were colorectal cancer （44%） and ovarian cancer （22%）. The percentage of obese patients was higher in Group A （P=0.013）. There was no differenc