Screening and Verifying of Metastasis-associated Genes of Human Lung Cancer Cell Lines with Different Metastatic Potential

Background and Objective Lung cancer is the most lethal malignangy that threatens human health and lives nowadays in the world, The overall cure rate of lung cancer is only 13% -15%, Tumor metastasis is a major cause of poor prognosis and death in lung cancer patients, The high mortality is probably attributed to early metastasis. Metastasis is the multi-step and multi-stage process regulated by multi-factors, The precise mechanisms promoting lung cancer metastasis still unclear to date. A series of tumor associated genes and signal transduction pathways may be involved in this procedure. Recently several well-known markers correlated with poor metastasis prognosis in cancer patients by immunohistochemistry have been reported, but none of them have been proved to be sufficiently useful in clinical diagnosis. Attempts to identify the genes involved in the metastasis are pivotal for the prediction of HNSCC behavior.