The Regulating Effect of the Nm23-H1 Gene for PKA Signal Pathway of Lung Cancer Cell and Its Molecular Mechanism

Backgroud and Objective Lung cancer has become the most frenquent malignant tumor in the world which its mortality and morbidity is increasing fastest among all the cancers,and it also has become the No1 malignant tumors which is harmful to human health and life, and the tirst killer in all cancers. Meanwhile,tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the main cause of failure to cure and lose their life of the patients with lung cancer. It is a complex biological consquence that involved in many factors, genes, signal pathways and processes. The study of lung cancer cell signal transduction will illuminate the molecules mechanism of tumor invasion and metastasis, provide a new targeting molecules and pathway for retro-transduction of the signal pathway It has been proved that nm23-H1 is a putative tumor metastasis suppressor gene.there exists an close relationship between the abnormality of nm23-H1 structure and function and the tumor metastatic ability.