5-(1H-Benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-Pyrrolium Hexachloroantimonate (BDMP®): A Highly Efficient Immonium Type Peptide Coupling Reagent

5-(1H-Benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-Pyrrolium Hexachloroantimonate (BDMP®): A Highly Efficient Immonium Type Peptide Coupling Reagent

HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution and solid phase with good yield, low racemiza...

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Veröffentlicht in:Chemistry letters 1999-11, Vol.28 (11), p.1163-1164
Hauptverfasser: Li, Peng, Xu, Jie Cheng
Format: Artikel
Sprache:eng
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Zusammenfassung:HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution and solid phase with good yield, low racemization and fast reaction rate.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1999.1163