Pharmacokinetics, Drug-Likeness, Medicinal Properties, Molecular Docking Analysis of Substituted Β-Lactams Synthezied via [Bmim][Pf6]/]Et3nh]+[Hso4]- Catalyzed Coupling Reaction

Our examination planned to synthesize the azido β-lactam under reactive ionic liquids for new synthetic organic methodologies. These endeavors may provide more clarity to the analysis in the systems of natural responses utilizing ionic liquid as response media. The Schiff base witnesses quick responses with azido acidic acid in a [bmim] [PF6]/[Et3NH]+[HSO4]- dissolvable framework, under mellow and unbiased response conditions to afford the corresponding azido β-lactam in high to quantitative yields. The library of substituted 3-azido-4-phenyl-1-(-phenylthiazol-2-yl) azetidin-2-one (3a-s) has screened antibacterial movement against clinically secluded Gram-positive bacteria, for example, Staphylococcus aureus, Gram-negative microbes Escherichia coli and Pseudomonas aeruginosa and for antifungal action against Candida albicans strains. Further, the synthesized compound has also assessed by a computational investigation by cooperation with the dynamic site of E150K from MRSA (PDB ID-4BL2). We present the new SwissADME web utensil that gives free access to a pool of quick yet reliable analytical models for physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry. Among them, in-house capable technique, for example, BOILED-Egg, iLOGP, and Bioavailability Radar, are readily available on the web.