UTICAJ FARMAKODINAMSKIH PARAMETARA NA SUDBINU ANTIBIOTIKA

Introduction. When treating bacterial infections, one of the most important things, the main stone in the treatment, is optimal dosing of antibiotic. Core In the past, pharmacokinetic parameters, mainly C max, T max were the only ones that determined dosing od antibiotics. In the last two decades it was recognised that pharmacodynamic parameters- way of killing the bacteria as well as the presence and duration of postantibiotic effect- significantly influence the dosing of antibiotics. The most important examples are ampicillin- semisynthetic penicillin, and cefaclor, second generation cefalosporine antibiotic. For cefaclor, during lounching, producers recommended longer than optimal period between the doses, without increasing the dose. As a consequence, rapir resistence developed, and cefaclor, otherwise good antibiotc, is being in the proces of withdrawing from the market.