Psoriasis and depression: Elucidating the molecular interplay

Psoriasis and depression are prevalent and often co-occurring disorders, yet the molecular basis of their association remains inadequately understood. This review aims to synthesize current knowledge on the molecular links between psoriasis and depression, highlighting potential common pathways and mechanisms. We conducted a comprehensive literature search, examining studies that explored the molecular aspects of psoriasis and depression, with a specific focus on research identifying shared molecular pathways and markers. Our review reveals significant intersections in the molecular pathways of psoriasis and depression, particularly in the realms of inflammation, immune response, and genetic predispositions. Key findings include the role of pro-inflammatory cytokines, which are elevated in both conditions, and genetic markers that may predispose individuals to both disorders. Understanding the molecular interplay between psoriasis and depression can offer valuable insights into new therapeutic approaches and the potential for personalized medicine. This review underscores the need for integrated management strategies in patients suffering from both conditions and highlights areas for future research.