Therapy management of treatment-resistant depression

Treatment resistant depression (TRD) is a subgroup of Major Depressive Disorder that does not respond to typical or first-line treatment approaches. Treatment-resistant depression is diagnosed when two appropriate antidepressant therapies fail. TRD may also be connected to lengthy stays in a hospital for medical attention. To distinguish authentic TRD, a number of definitions and standards have been presented, but no single definition or standard has yet gained acceptance. As a result, TRD poses unique difficulties for therapeutic strategies and efficient therapies. Recent meta-analyses, original studies of the PubMed literature were compiled. In this article, we'll try to give a comprehensive overview of TRD treatment options and discuss the difficulties that come with treating this condition.