IDDF2018-ABS-0133 Performance of non-invasive blood parameters for detecting significant liver fibrosis in patients with chronic hepatitis b

BackgroundSince liver biopsy is invasive and Fibroscan has limited availability, various non-invasive blood parameters need evaluation to find the most useful parameter for detection of significant fibrosis in patients with chronic hepatitis B(CHB).MethodsIn this retrospective study, records of patients who underwent liver biopsy for treatment naive CHB, were evaluated to obtain various non-invasive blood parameters (AST-platelet ratio index[APRI], Fibrosis-4[Fib-4], GGT-platelet ratio[GPR], GGT-to-albumin ratio[GAR]), in addition to Fibroscan, to detect significant fibrosis and compared these with fibrosis stage of liver biopsy.Abstract IDDF2018-ABS-0133 Table 1 Parameter Formula N AUROC 95% CI P value Best cut-off PPV NPV APRI (AST/ULN)*100/Plt 107 0.687 0.533–0.840 0.030 0.935 33% 93% Fib-4 (Age*AST)/(Plt*?ALT) 107 0.735 0.590–0.880 0.006 2.324 37% 93% GPR (GGT/ULN)*100/Plt 91 0.727 0.577–0.876 0.015 0.444 28% 95% GAR GGT/Alb 90 0.688 0.516–0.860 0.037 17.848 35% 92% Fibroscan - 92 0.768 0.633–0.902 0.009 5.35 17% 100% ResultsA total of 125 were included (median age 34 [range 11–82] years, 74%males). Most (83%) patients were HBeAg negative. Liver biopsy revealed nil/mild fibrosis (Ishak