ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECTS OF AN ETHANOLIC EXTRACT OF THE AERIAL PARTS OF HILLERIA LATIFOLIA (LAM.) H. WALT. (PHYTOLACCACEAE)
Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts o...
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Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-06, Vol.9 (1) |
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Zusammenfassung: | Various parts of the perennial herb Hilleria latifolia (Lam.) H.
Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional
medicine for the treatment of several inflammatory-related disorders.
The present study examined the anti-inflammatory effect of an ethanolic
extract of the aerial parts of Hilleria latifolia (HLE) in acute and
chronic inflammation models. Since free radicals and reactive oxygen
species are implicated in inflammatory diseases, the antioxidant
potential of HLE was also investigated in in vitro experimental models.
HLE (10-300 mg kg-1, p.o.), either preemptively or curatively,
significantly inhibited carrageenan-induced foot oedema in 7-day old
chicks. Similarly, the NSAID diclofenac (10-100 mg kg-1, i.p.) and the
steroidal anti-inflammatory agent dexamethasone (0.3-3 mg kg-1, i.p.)
dose-dependently reduced the oedema in both pre-emptive and curative
treatments. In the Freund's adjuvant induced-arthritis model in
rats, HLE as well as the positive controls, dexamethasone and
methotrexate, showed significant anti-arthritic properties when applied
to established adjuvant arthritis. HLE (10-300 mg kg-1, p.o.)
significantly reduced oedema in the ipsilateral paw of rats but failed
to prevent systemic arthritic spread. The DMARD methotrexate (0.1-1 mg
kg-1, i.p.) and dexamethasone (0.3-3 mg kg-1, i.p.) reduced
significantly the total polyarthritic oedema as well as the spread of
the arthritis from the ipsilateral to the contralateral paws of the
treated animals. The extract (0.03-1.00 mg ml-1) exhibited Fe3+
reducing activity, scavenged DPPH and prevented lipid peroxidation.
These findings suggest that the extract exerts in vivo antiinflammatory
activity after oral administration and also has antioxidant properties
which may contribute to its activity. |
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ISSN: | 0189-6016 |