Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats
Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders. Previous studies have shown that the methanolic stem bark extract of Crossopteryx febrifuga possesses s...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2012-01, Vol.8 (3) |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Adeola, Salawu Oluwakanyinsola Yahaya, Tijani Adeniyi Hafsatu, Babayi Chinwe, Nwaeze Angela Ezeonu, Chidimma MaryJane Sunday, Igwe Adanna, Ndukuba Mary |
| description | Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae)
are widely used in Northern Nigeria in the therapeutic management of
trypanosomiasis, malaria and painful inflammatory disorders. Previous
studies have shown that the methanolic stem bark extract of
Crossopteryx febrifuga possesses significant analgesic and
anti-inflammatory properties possibly mediated via Non-selective
inhibition of cyclo-oxygenase pathways. In the present study, the
methanolic stem bark extract of Crossopteryx febrifuga was evaluated
against ethanol- and piroxicam-induced ulceration in rats.
Histopathological studies of the rat stomach tissues were also carried
out in order to determine its safety profile on the gastrointestinal
tract (git). The extract (25, 50 and100 mg extract/kg body weight)
significantly (P |
| format | Article |
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are widely used in Northern Nigeria in the therapeutic management of
trypanosomiasis, malaria and painful inflammatory disorders. Previous
studies have shown that the methanolic stem bark extract of
Crossopteryx febrifuga possesses significant analgesic and
anti-inflammatory properties possibly mediated via Non-selective
inhibition of cyclo-oxygenase pathways. In the present study, the
methanolic stem bark extract of Crossopteryx febrifuga was evaluated
against ethanol- and piroxicam-induced ulceration in rats.
Histopathological studies of the rat stomach tissues were also carried
out in order to determine its safety profile on the gastrointestinal
tract (git). The extract (25, 50 and100 mg extract/kg body weight)
significantly (P<0.05) and dose-dependently reduced ulcer index
induced by ethanol (24 - 92%) and piroxicam (81.81- 98.60%).
Histopathology of the rat stomach tissues from control and
extract-treated groups at 25 mg/kg body weight extract showed mild
inflammation characterized by infiltration of inflammatory cells, while
the extract treated groups at 50 and 100mg/kg body weight and 200 mg
misoprostol/kg body weight group showed no obvious lesions. These
results showed that the extract had no deleterious effects and was
cytoprotective on the gastrointestinal tract (git). It can thus be
developed as a safe alternative to conventional non-steroidal
anti-inflammatory drugs (NSAIDs) for the management of painful
inflammatory disorders.</description><identifier>ISSN: 0189-6016</identifier><language>eng</language><publisher>African Ethnomedicines Network</publisher><subject>Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2012-01, Vol.8 (3)</ispartof><rights>Copyright 2011 Afr. J. Trad. CAM.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,79168</link.rule.ids></links><search><creatorcontrib>Adeola, Salawu Oluwakanyinsola</creatorcontrib><creatorcontrib>Yahaya, Tijani Adeniyi</creatorcontrib><creatorcontrib>Hafsatu, Babayi</creatorcontrib><creatorcontrib>Chinwe, Nwaeze Angela</creatorcontrib><creatorcontrib>Ezeonu, Chidimma MaryJane</creatorcontrib><creatorcontrib>Sunday, Igwe</creatorcontrib><creatorcontrib>Adanna, Ndukuba Mary</creatorcontrib><title>Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats</title><title>African journal of traditional, complementary, and alternative medicines</title><description>Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae)
are widely used in Northern Nigeria in the therapeutic management of
trypanosomiasis, malaria and painful inflammatory disorders. Previous
studies have shown that the methanolic stem bark extract of
Crossopteryx febrifuga possesses significant analgesic and
anti-inflammatory properties possibly mediated via Non-selective
inhibition of cyclo-oxygenase pathways. In the present study, the
methanolic stem bark extract of Crossopteryx febrifuga was evaluated
against ethanol- and piroxicam-induced ulceration in rats.
Histopathological studies of the rat stomach tissues were also carried
out in order to determine its safety profile on the gastrointestinal
tract (git). The extract (25, 50 and100 mg extract/kg body weight)
significantly (P<0.05) and dose-dependently reduced ulcer index
induced by ethanol (24 - 92%) and piroxicam (81.81- 98.60%).
Histopathology of the rat stomach tissues from control and
extract-treated groups at 25 mg/kg body weight extract showed mild
inflammation characterized by infiltration of inflammatory cells, while
the extract treated groups at 50 and 100mg/kg body weight and 200 mg
misoprostol/kg body weight group showed no obvious lesions. These
results showed that the extract had no deleterious effects and was
cytoprotective on the gastrointestinal tract (git). It can thus be
developed as a safe alternative to conventional non-steroidal
anti-inflammatory drugs (NSAIDs) for the management of painful
inflammatory disorders.</description><subject>Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer</subject><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNpjYeA0MLSw1DUzMDTjYOAqLs4yMDC2MDQy52RwdE8sLinK1w0oyi9JTS7JLEtVcE1LA7IU_NMUnIvyi4vzC0pSiyorFNJSk4oy00rTExUy8xTCM4tLEosUghJLinkYWNMSc4pTeaE0N4Oem2uIs4duUmZ-TmZeanxBUWZuYlFlfHJRZmI8TLAkGYgMDYHOMCZZAwDnjkNj</recordid><startdate>20120115</startdate><enddate>20120115</enddate><creator>Adeola, Salawu Oluwakanyinsola</creator><creator>Yahaya, Tijani Adeniyi</creator><creator>Hafsatu, Babayi</creator><creator>Chinwe, Nwaeze Angela</creator><creator>Ezeonu, Chidimma MaryJane</creator><creator>Sunday, Igwe</creator><creator>Adanna, Ndukuba Mary</creator><general>African Ethnomedicines Network</general><scope>RBI</scope></search><sort><creationdate>20120115</creationdate><title>Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats</title><author>Adeola, Salawu Oluwakanyinsola ; Yahaya, Tijani Adeniyi ; Hafsatu, Babayi ; Chinwe, Nwaeze Angela ; Ezeonu, Chidimma MaryJane ; Sunday, Igwe ; Adanna, Ndukuba Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_tc_tc110383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adeola, Salawu Oluwakanyinsola</creatorcontrib><creatorcontrib>Yahaya, Tijani Adeniyi</creatorcontrib><creatorcontrib>Hafsatu, Babayi</creatorcontrib><creatorcontrib>Chinwe, Nwaeze Angela</creatorcontrib><creatorcontrib>Ezeonu, Chidimma MaryJane</creatorcontrib><creatorcontrib>Sunday, Igwe</creatorcontrib><creatorcontrib>Adanna, Ndukuba Mary</creatorcontrib><collection>Bioline International</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adeola, Salawu Oluwakanyinsola</au><au>Yahaya, Tijani Adeniyi</au><au>Hafsatu, Babayi</au><au>Chinwe, Nwaeze Angela</au><au>Ezeonu, Chidimma MaryJane</au><au>Sunday, Igwe</au><au>Adanna, Ndukuba Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><date>2012-01-15</date><risdate>2012</risdate><volume>8</volume><issue>3</issue><issn>0189-6016</issn><abstract>Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae)
are widely used in Northern Nigeria in the therapeutic management of
trypanosomiasis, malaria and painful inflammatory disorders. Previous
studies have shown that the methanolic stem bark extract of
Crossopteryx febrifuga possesses significant analgesic and
anti-inflammatory properties possibly mediated via Non-selective
inhibition of cyclo-oxygenase pathways. In the present study, the
methanolic stem bark extract of Crossopteryx febrifuga was evaluated
against ethanol- and piroxicam-induced ulceration in rats.
Histopathological studies of the rat stomach tissues were also carried
out in order to determine its safety profile on the gastrointestinal
tract (git). The extract (25, 50 and100 mg extract/kg body weight)
significantly (P<0.05) and dose-dependently reduced ulcer index
induced by ethanol (24 - 92%) and piroxicam (81.81- 98.60%).
Histopathology of the rat stomach tissues from control and
extract-treated groups at 25 mg/kg body weight extract showed mild
inflammation characterized by infiltration of inflammatory cells, while
the extract treated groups at 50 and 100mg/kg body weight and 200 mg
misoprostol/kg body weight group showed no obvious lesions. These
results showed that the extract had no deleterious effects and was
cytoprotective on the gastrointestinal tract (git). It can thus be
developed as a safe alternative to conventional non-steroidal
anti-inflammatory drugs (NSAIDs) for the management of painful
inflammatory disorders.</abstract><pub>African Ethnomedicines Network</pub></addata></record> |
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| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2012-01, Vol.8 (3) |
| issn | 0189-6016 |
| language | eng |
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| source | Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer |
| title | Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats |
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