Gastro-Protective Effect Of Crossopteryx febrifuga in Wistar Rats
Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders. Previous studies have shown that the methanolic stem bark extract of Crossopteryx febrifuga possesses s...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2012-01, Vol.8 (3) |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae)
are widely used in Northern Nigeria in the therapeutic management of
trypanosomiasis, malaria and painful inflammatory disorders. Previous
studies have shown that the methanolic stem bark extract of
Crossopteryx febrifuga possesses significant analgesic and
anti-inflammatory properties possibly mediated via Non-selective
inhibition of cyclo-oxygenase pathways. In the present study, the
methanolic stem bark extract of Crossopteryx febrifuga was evaluated
against ethanol- and piroxicam-induced ulceration in rats.
Histopathological studies of the rat stomach tissues were also carried
out in order to determine its safety profile on the gastrointestinal
tract (git). The extract (25, 50 and100 mg extract/kg body weight)
significantly (P |
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| ISSN: | 0189-6016 |