Research Paper - ANTIHYPERGLYCEMIC EFFECT OF Bridelia ndellensis ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of B. ndellensis had no hypoglycemic effect in type...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2005-12, Vol.2 (2) |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg)
of Bridelia ndellensis stem bark on the blood glucose levels in
streptozotocin-induced types 1 and 2 diabetic rats at different
prandial states were studied. The ethanol extract of B. ndellensis had
no hypoglycemic effect in type 1 diabetic rats in fasting and
postprandial glucose load conditions and, in type 2 diabetic rats in
fasting condition. However, the extract, and its ethyl acetate and
dichloromethane fractions significantly lowered blood glucose levels in
type 2 diabetic rats when fed simultaneously with glucose. The active
principles responsible for the antihyperglycaemic effect are
concentrated in the ethyl acetate and dichloromethane fractions of the
extract. |
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| ISSN: | 0189-6016 |