Cytogenetic analysis in couples with recurrent spontaneous abortion

Background: Recurrent abortion is a difficult medical problem happening in about 1-2% of fertile women. Most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. Objective: The present study tries to find the rate of chromosomal abnormalit...

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Veröffentlicht in:Iranian journal of reproductive medicine 2007-04, Vol.4 (1)
1. Verfasser: Razieh Dehghani Firoozabadi, Seyed Mehdi Klantar,Seyed Mohammad Seyed-Hasani, Nasrin Ghasemi, Ph.D., Maryam Asgharnia, Mohammad Hasan Sheikhha
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Sprache:eng
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Zusammenfassung:Background: Recurrent abortion is a difficult medical problem happening in about 1-2% of fertile women. Most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. Objective: The present study tries to find the rate of chromosomal abnormalities in couples with recurrent pregnancy loss. Materials and Methods: In total 165 couples were referred to genetic counselling clinic with a history of at least three previous abortions. In all women antibodies against toxsoplasmose, rubella and cytomegalovirus (CMV) were analysed by ELIZA. In 88 couples karyotyping was conducted by analysis of G and/or C banding. Metaphase spreads were made from phytohaemaglutinin-stimulatedperipheral lymphocytes using standard cytogenetic techniques. The chromosomal status was analyzed using CytoVision Ultra ver.4.0 from Applied Imaging. The χ2-test and ANOVA were used for statistical evaluation. The level of p
ISSN:1680-6433