Controlled Release Formulation of Indomethacin Prepared With Bee Glue Extracts

Purpose: To prepare and evaluate new sustained release formulations of indomethacin based on extracts of propolis (bee glue). Methods: Standardization of propolis (bee glue) extracts was performed by high performance liquid chromatography (HPLC) and determination of the values of fat and fixed oils. Several indomethacin capsule formulations (F1 - F18) containing varying amounts of chloroform (0.75 - 75 mg) and ethanol extracts (30 - 75 mg) of propolis were prepared. The dissolution rate of the formulations was evaluated by USP dissolution (rotating basket) method I and the release data subjected to various kinetic models. Probable interaction between the drug and propolis extracts was studied by differential scanning calorimetry (DSC). Results: The results show that, although the release rate of formulations F1 - F7 did not show any significant difference (p