Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhäo) strains
Experimental models of S Schistosoma mansoni infections in mammals have contributed greatly in understanding the pathology and pathogenesis of human infection. The absence of earlier reviews regarding specific strains of the Amazon region prompted research, which the main objective was to describe h...
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Veröffentlicht in: | Memórias do Instituto Oswaldo Cruz 2007-01, Vol.101 |
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Zusammenfassung: | Experimental models of S Schistosoma mansoni infections in mammals
have contributed greatly in understanding the pathology and
pathogenesis of human infection. The absence of earlier reviews
regarding specific strains of the Amazon region prompted research,
which the main objective was to describe histopathological lesions in
different phases of schistosomiasis in a murine model using PC
(Pará) and LILA (Maranhäo) S. mansoni strains. One hundred
and eighty young female albino swiss mice (Mus musculus) were used and
were randomly divided into five groups (PC-01, PC-02, LILA-01, LILA-02,
and controls), according to the number of cercariae injected and the
strain adopted. Animals were sacrificed in predetermined periods (35,
56, 112, 156, and 180 days) in an attempt to follow the evolution of
the disease in the histological sections of their tissues at different
phases of infection. Our findings were compatible with the data already
described by others authors using different strains of S. mansoni,
making it possible to identify some peculiarities, which are discussed
in this work. In conclusion, the strains of parasite used did not
modify the histopathological findings in the tissues of infected mice
in any significant way when compared with the results of other studies
using different strains. |
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ISSN: | 1678-8060 |