Drug Review - Insulin glargine: A long acting insulin analog

The main goal of treatment of diabetes mellitus (DM) is to maintain long term near normoglycemia. Insulin therapy plays a pivotal role in the management of DM. Most insulin preparations and insulin delivery systems, do not mimic the physiological insulin secretion in the body, leading to impaired metabolic ocntrol and increased hypoglycemic attacks. Insulin glargine is newer, long acting insulin analog with duration of action of 24 hr. It better efficacy than the currently used insulin replacement therapies with no increased side effects. In the surrent scenario, thought it is difficult to achieve an ideal insulin replacement therapy, insulin glargine is definitely a positive step in theat direction.