Use of Bentonite Clay for the Reduction of Cyanide Poisoning after Consumption of Cassava waste water by Wistar Albino Rat
The in vivo study of the effect of bentonite on cyanide poisoning and its effect on plasma urea was investigated. A total of 45 wistar albino rats were used. The rats were divided into four groups and a control group. Each group had nine rats including the control. Groups 1, 2, 3, and 4 were given a...
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Veröffentlicht in: | Journal of applied science & environmental management 2017-01, Vol.20 (3) |
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Sprache: | eng |
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Zusammenfassung: | The in vivo study of the effect of bentonite on cyanide poisoning and
its effect on plasma urea was investigated. A total of 45 wistar albino
rats were used. The rats were divided into four groups and a control
group. Each group had nine rats including the control. Groups 1, 2, 3,
and 4 were given a daily dose of 0.4ml of cassava waste water
containing a sub-lethal amount of cyanide (2.16 x 10-3 mg). Groups 2,
3, and 4 were counter administered with 0.2ml, 0.4ml, and 0.8ml of 7%
bentonite solution respectively. Administration of bentonite was done
simultaneously with the cyanide administration. At the end of each week
three animals were sacrificed from each group and the control and their
plasma urea level determined. The experiment which lasted for three
weeks showed that the sub-lethal amount of cyanide caused a significant
increase (p> 0.05) of plasma urea from 0.0300 ± 0.01mmol/L per
gram of rats in the control to 0.0375 ± 0.01 mmol/L per gram of
rats in group 1 which was fed with only cyanide. A counter treatment
with bentonite led to significant decrease (p>0.05) in plasma urea
from 0.0413 ± 0.10 mmol/L to 0.0249 ± 0.01 mmol/L per gram of
body weight of the rats. The reduction of plasma urea caused by
bentonite was also proportional to the amount of bentonite
administered. 0.2ml and 0.8ml of 7% bentonite solution caused a 5.08%
and 39.71% reduction of plasma urea level respectively. This suggests
that bentonite might have some preventive and therapeutic effects on
cyanide poisoning. © JASEM |
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ISSN: | 1119-8362 |