Kaposi Sarcoma: Changing Trend in Calabar, South Eastern Nigeria
Background/objective: Kaposi sarcoma (KS) is now the most frequently reported malignant skin tumour in some areas of Africa and was endemic in Africa before the advent of the human immunodeficiency virus (HIV) infection. The prevalence has increased with the emergence of HIV infection. The objective...
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Veröffentlicht in: | Annals of African medicine 2009-01, Vol.7 (3) |
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Zusammenfassung: | Background/objective: Kaposi sarcoma (KS) is now the most frequently
reported malignant skin tumour in some areas of Africa and was endemic
in Africa before the advent of the human immunodeficiency virus (HIV)
infection. The prevalence has increased with the emergence of HIV
infection. The objective of this report is to describe the frequency,
current clinical pattern, and anatomic distribution of KS in Calabar,
south-eastern Nigeria and compare this with total malignant skin
tumour. Method: All the patients with histologic diagnosis of KS
presenting to the University of Calabar Teaching Hospital from January
2005 and December 2006 were analyzed as part of the wider study of
malignant skin tumorus. Diagnosis of HIV was based upon enzyme linked
immunosorbent assay. Results: In our study, there were 11 patients (7
males and 4 females), with a male: female ratio of 1.75: 1. This was
the commonest malignant skin tumor (38%) followed by squamous cell
carcinoma (SCC) (34.5%) and the age ranged from 21 - 60 years
(mean 42.9years). Nine patients (81.8%) were HIV positive including the
4 females (age ranged from 21 -45 years) and 2(18.2%) HIV negative,
aged 59 and 60years. The lower limb was the commonest site (50%).
Atypical lesions involved the eyelids/ nose and penis. Conclusion: KS
is now the commonest malignant skin tumour in our region with the HIV
related KS as the commonest clinical type. Successful prevention and
treatment of HIV infection would reduce the prevalence of this tumour.
Contexte: Le sarcome de Kaposi est à l'heure actuelle la
plus fréquente des tumeurs malignes cutanées dans certaines
zones d'Afrique. Il sévissait à l'état
endémique avant l'avènement de l'infection par le
virus de l'immunodéficience humaine (VIH). La prévalence
s'est accrue avec l'émergence l'infection par le
VIH. L'objectif de ce travail est de décrire la
fréquence, le mode de présentation clinique usuel, et la
distribution anatomique du sarcome de Kaposi à Calabar dans le
Sud-est du Nigeria et de procéder a une comparaison avec
l'ensemble des tumeurs malignes cutanées. Méthode:
Tous les patients ayant un sarcome de Kaposi confirme histologiquement
et ayant consulte au Centre Hospitalier Universitaire de Calabar de
janvier 2005 a décembre 2006 ont été considéré
comme un échantillon de la population des tumeurs malignes
cutanées. Le diagnostic de l'infection VIH était base
sur la technique ELISA. Résultats: Notre étude comptait 11
patients (7 hommes et 4 femmes), avec un sexe |
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ISSN: | 1596-3519 |